Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		1pky (A)
  Conformer 2
(PDB) 		1pky (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 374 0.46   3 - 71   113 - 115   160 - 166   168 - 468
2 55 0.44   72 - 112   116 - 159   167 - 167

Sequence


           _____________________________________________________________________71______________________________________112________ 
 1pky(A) : MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVG 
         :                                                                                                                          
 1pky(C) : MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIR-------------------------------mVAVTYEGFTTDLSVG 
           _____________________________________________________________________71______________________________________112________ 

           ____________________________________159____166__________________________________________________________________________ 
 1pky(A) : NTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGI 
         :                                                                                                                          
 1pky(C) : NTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGI 
           ____________________________________159____166__________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1pky(A) : MVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEkLRITEAVCRGAVETA 
         :                                                                                                                          
 1pky(C) : MVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEkLRITEAVCRGAVETA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________                 
 1pky(A) : EKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL                 
         :                                                                                                                          
 1pky(C) : EKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL                 
           ________________________________________________________________________________________________________                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		7.9
Translation
(A) 		-0.2
Closure
(%) 		5.0
Bending Residues
( green ) 		  71 - 72
  112 - 113
  115 - 116
  159 - 162
  166 - 175
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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