Replicative DNA Helicase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Replicative DNA Helicase
  Conformer 1
(PDB) 		4nmn (A)
  Conformer 2
(PDB) 		4nmn (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 270 1.94   155 - 436
2 131 2.4   10 - 147

Sequence


           ________________________________________________________________________________________________________________________ 
 4nmn(A) : PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSEYGNKLDFVLIKDHLEKKNLLQiDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENK 
         :                                                                                                                          
 4nmn(B) : PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWSE-gNKLDFVLIKDHLEKK---pIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKENK 
           ________________________________________________________________________________________________________________________ 

           ______________147_______________________________________________________________________________________________________ 
 4nmn(A) : DFHTLIEEAQSRIFSIAES--sTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSM 
         :                                                                                                                          
 4nmn(B) : DFHTLIEEAQSRIFSIAESATSTQFYHVKDVAEEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGKTAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSM 
           ______________147_______________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4nmn(A) : MSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSREVEKRSDKRP 
         :                                                                                                                          
 4nmn(B) : MSEVPLFKIRSGSISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEFVAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLS--------kRP 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________                                                      
 4nmn(A) : QLADLRESGQIEQDADLILFLHRPEYYTKKPNeQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANLE                                                      
         :                                                                                                                          
 4nmn(B) : QLADLRESGQIEQDADLILFLHRPEYYT--pEEQGIAEVIIAKQRQGPTDIVKLAFIKEYTKFANL*                                                      
           ___________________________________________________________________                                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		122.2
Translation
(A) 		-15.2
Closure
(%) 		25.3
Bending Residues
( green ) 		  147 - 164
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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