M-Calpain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name M-Calpain
  Conformer 1
(PDB) 		1kxr (A)
  Conformer 2
(PDB) 		1ziv (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 173 1.63   43 - 222
2 128 1.19   223 - 350

Sequence


           ________________________________________________________________________________________________________________________ 
 1kxr(A) : NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDSWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQ 
         :                                                                                                                          
 1ziv(A) : ********SFEQMRQECLQRGTLFEDADFPASNSSLFYSpQIP-------FVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQ 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________221___________________________________________________ 
 1kxr(A) : LWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGH 
         :                                                                                                                          
 1ziv(A) : FWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGH 
           __________________________________________________________________203___________________________________________________ 

           ___________________________________________________________________________________                                      
 1kxr(A) : AYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQL-RVKMEDGEFWMSFRDFIREFTKLEICN**                                      
         :                                                                                                                          
 1ziv(A) : AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLT                                      
           ___________________________________________________________________________________                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		48.4
Translation
(A) 		1.7
Closure
(%) 		50.7
Bending Residues
( green ) 		  221 - 223
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download