DynDom - Protein Domain Motions

Eh Domain-Containing Protein 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Eh Domain-Containing Protein 2
Conformer 1 (PDB)	4cid (A)
Conformer 2 (PDB)	5mtv (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	207	2.41	58 - 287
2	146	1.38	18 - 57 288 - 398

Sequence

`____________________________________________57__________________________________________________________________________` `4cid(A) : FSWkKaIRTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKP-vLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAV-hGETEGTVPGNAL--nP---------FGNT` `:` `5mtv(A) : **GGSQTVTGGLRSLYQRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNA` `____________________________________________60__________________________________________________________________________` `________________________________________________________________________________________________________________________` `4cid(A) : FLNRF-cAQLPNQVLESISIIDTPGILSGsRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKAD-vETQQL-rVYGAL-wALGKVVGTPEVLRVYIGS` `:` `5mtv(A) : FLNRFMCSQLPNQVLKSISIIDSPGILi-SRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGS` `________________________________________________________________________________________________________________________` `____________________________287_________________________________________________________________________________________` `4cid(A) : FWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKE-pTVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQ--KqELLaHDFTKFHSLKP` `:` `5mtv(A) : FWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPNMFGKENKKRELIYRLPEIYVQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKP` `____________________________290_________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4cid(A) : KLLEALDD-lAQDIAKL-pLLRQEELESVEAGVAGGAFEGTRgPFVdAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWvGTKLPNSVLGRIWKLSDVDRDGlDDEEFALASHLIEAK` `:` `5mtv(A) : KLIEAVDNMLTNKISSLMGLISQE********************************************************************************************` `________________________________________________________________________________________________________________________` `_______________________` `4cid(A) : LEGHGLPTNLPRRLVPPSKRRQK` `:` `5mtv(A) : *********************` `_______________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	56.5
Translation (A)	-1.1
Closure (%)	99.3
Bending Residues ( green )	57 - 58 287 - 288
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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