DynDom - Protein Domain Motions

Myosin

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin
Conformer 1 (PDB)	1vom (A)
Conformer 2 (PDB)	2aka (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	64	1.73	487 - 505 689 - 745
2	401	1.86	211 - 246 255 - 445 451 - 486 511 - 648
3	255	2.25	4 - 200 247 - 254 446 - 450 506 - 510 649 - 688

Sequence

`________________________________________________________________________________________________________________________` `1vom(A) : NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPDERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGL` `:` `2aka(A) : NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGL` `________________________________________________________________________________________________________________________` `____________________________________________________________________________200_________________________________________` `1vom(A) : FLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRNQ----gVLEQQILQANPILEAFGNAKTTRNNNSSRFGK` `:` `2aka(A) : FLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRNQANGSGVLEQQILQANPILEAFGNAKTTRNNNSSRFGK` `____________________________________________________________________________200_________________________________________` `_245______254___________________________________________________________________________________________________________` `1vom(A) : FIEIQFNNAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDEDEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEK` `:` `2aka(A) : FIEIQFNSAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEK` `_245______254___________________________________________________________________________________________________________` `_______________________________________________________________________________443____450_______________________________` `1vom(A) : GAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCSERAAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQF` `:` `2aka(A) : GAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQF` `_______________________________________________________________________________443____450_______________________________` `_485_____________501__506_______________________________________________________________________________________________` `1vom(A) : FNHHMFKVEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK` `:` `2aka(A) : FNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK` `_485_____________501__506_______________________________________________________________________________________________` `____________________________________________648_______________________________682_______________________________________` `1vom(A) : DSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAP-vPRD----qK` `:` `2aka(A) : DSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNVPRDAEDSQK` `____________________________________________648_______________________________682_______________________________________` `____________________________________________` `1vom(A) : AT-------nIDPEQYRFGITKIFFR******************` `:` `2aka(A) : ATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEAREQRISEI` `____________________________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	74.5	-0.4	20.9	485 - 487	Bending Region Analysis
1	3	77.5	2.6	49.3	501 - 510 682 - 691	Bending Region Analysis
3	2	20.9	1.9	68.2	200 - 211 245 - 247 254 - 255 443 - 446 450 - 454 506 - 512 648 - 649	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file

Download