DynDom - Protein Domain Motions

Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11
Conformer 1 (PDB)	5u6o (A)
Conformer 2 (PDB)	3u11 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	147	1.83	403 - 476 488 - 541 546 - 565
2	34	1.52	477 - 487 542 - 545 566 - 584

Sequence

`________________________________________________________________________________________________________________________` `5u6o(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNsSEIILDPKVIKM` `:` `3u11(A) : **********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5u6o(A) : NYLKSWFVVDFISSIPVDYIFLIVEKGrALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQ` `:` `3u11(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5u6o(A) : YSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNF` `:` `3u11(A) : ****************************************************DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINF` `________________________________________________________________________________________________________________________` `_________476________487___________________________________________________541_545_________________565___________________` `5u6o(A) : NCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE` `:` `3u11(A) : N-rKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE` `_________596________607___________________________________________________661_665_________________685___________________` `______________` `5u6o(A) : TV**********` `:` `3u11(A) : TVALDRLDRIGKKN` `______________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	24.5
Translation (A)	-0.1
Closure (%)	95.4
Bending Residues ( green )	476 - 477 487 - 488 541 - 542 545 - 546 565 - 566
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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