DynDom - Protein Domain Motions

Transportin-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Transportin-1
Conformer 1 (PDB)	2h4m (B)
Conformer 2 (PDB)	2ot8 (B)
Window Length	13
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	751	0.82	69 - 884
2	21	5.23	21 - 48

Sequence

`____________________________________48__________________________________________________________________________________` `2h4m(B) : KPDEQGLQQILQLLKESQSPDTTIQRTVQQKpDF--NNYLIFVLTsEDEPTRSLSGLILKNN----fQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKL` `:` `2ot8(B) : ****QGLQQILQLLKESQSPDTTIQRTVQQKLEQLNnNYLIFVLT---KLKrSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKL` `____________________________________48__________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(B) : CSLLDSEDYNTCEGAFGALQKICED---pLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYML` `:` `2ot8(B) : CSLLDSEDYNTCEGAFGALQKICEDSAEpLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYML` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(B) : QRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLK-tISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQ` `:` `2ot8(B) : QRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKdTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(B) : GMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLAD` `:` `2ot8(B) : GMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLAD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(B) : SVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILT` `:` `2ot8(B) : SVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(B) : LMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPML` `:` `2ot8(B) : LMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPML` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________________________` `2h4m(B) : QQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `:` `2ot8(B) : QQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `____________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	37.9
Translation (A)	-0.5
Closure (%)	5.8
Bending Residues ( green )	48 - 83
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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