Human Cyclin-Dependent Kinase 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Human Cyclin-Dependent Kinase 2
  Conformer 1
(PDB) 		1hcl (A)
  Conformer 2
(PDB) 		3py1 (A)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 227 1.3   32 - 65   82 - 151   166 - 292
2 46 1.63   7 - 31   66 - 81   161 - 165

Sequence


           _________________________________31_________________________58_____________________81___________________________________ 
 1hcl(A) : ****MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR----tEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 
         :                                                                                                                          
 3py1(A) : SPEFMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 
           _________________________________31_________________________58_____________________81___________________________________ 

           ____________________________147_________________________________________________________________________________________ 
 1hcl(A) : FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 
         :                                                                                                                          
 3py1(A) : FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 
           ____________________________147_________________________________________________________________________________________ 

           ______________________________________________________________                                                           
 1hcl(A) : KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL                                                           
         :                                                                                                                          
 3py1(A) : KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL                                                           
           ______________________________________________________________                                                           

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.8
Translation
(A) 		-2.2
Closure
(%) 		98.0
Bending Residues
( green ) 		  31 - 55
  58 - 66
  81 - 82
  147 - 166
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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