DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	2e4u (A)
Conformer 2 (PDB)	3sm9 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	266	1.03	32 - 194 327 - 464
2	164	0.63	195 - 326 465 - 498

Sequence

`________________________________________________________________________________________________________________________` `2e4u(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIPQI` `:` `3sm9(A) : RREIKIEGDLVLGGLFPINEKGT-tEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRAS---lLIAGVIGGSYSSVSIQVANLLRLFQIPQI` `________________________________________________________________________________________________________________________` `______________________194_______________________________________________________________________________________________` `2e4u(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAN` `:` `3sm9(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGR--iRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAS` `______________________169_______________________________________________________________________________________________` `__________________________________326___________________________________________________________________________________` `2e4u(A) : RVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQ---qVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC` `:` `3sm9(A) : RANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQnHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC` `__________________________________301___________________________________________________________________________________` `_________________________________________________464____________________________________________________________________` `2e4u(A) : PQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICI` `:` `3sm9(A) : PNTTKLCDAMKILDGKKLYKDYLLKINFTAPFN-----dSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWS******************************` `_________________________________________________439____________________________________________________________________` `___________________________________` `2e4u(A) : PCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `:` `3sm9(A) : *********************************` `___________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	29.2
Translation (A)	0.8
Closure (%)	99.7
Bending Residues ( green )	194 - 199 326 - 327 464 - 466
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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