DynDom - Protein Domain Motions

Transportin-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Transportin-1
Conformer 1 (PDB)	2h4m (A)
Conformer 2 (PDB)	2ot8 (B)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	468	1.25	58 - 575 592 - 607
2	295	0.64	576 - 591 608 - 886

Sequence

`________________________________________________________________________________________________________________________` `2h4m(A) : KPDEQGLQQILQLLKESQSPDTTIQRTVQQKpDF--NNYLIFVLTKLKSEDEPTRSLSGLILKNNVK--fQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLL` `:` `2ot8(B) : ****QGLQQILQLLKESQSPDTTIQRTVQQKLEQLNnNYLIFVLTKLK------rSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(A) : PKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRL` `:` `2ot8(B) : PKLCSLLDSEDYNTCEGAFGALQKICEDSAE---------pLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(A) : LPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLK-tISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGI` `:` `2ot8(B) : LPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKdTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(A) : LVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNL` `:` `2ot8(B) : LVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNL` `________________________________________________________________________________________________________________________` `__________________________________575_____________591_____________607___________________________________________________` `2h4m(A) : LILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGN` `:` `2ot8(B) : LILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGN` `__________________________________575_____________591_____________607___________________________________________________` `________________________________________________________________________________________________________________________` `2h4m(A) : IEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL` `:` `2ot8(B) : IEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________` `2h4m(A) : GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `:` `2ot8(B) : GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `________________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.0
Translation (A)	-0.3
Closure (%)	0.5
Bending Residues ( green )	575 - 576 591 - 592 607 - 608
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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