Type II DNA Topoisomerase Vi Subunit B

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Type II DNA Topoisomerase Vi Subunit B
  Conformer 1
(PDB) 		1z59 (A)
  Conformer 2
(PDB) 		1z5a (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 272 1.68   27 - 92   103 - 103   112 - 234   237 - 313   345 - 345   347 - 348   377 - 379
2 180 2.04   11 - 26   93 - 102   104 - 111   235 - 236   314 - 344   346 - 346   349 - 376   380 - 467

Sequence


           _____________________26________________________________________________________________92____________108________________ 
 1z59(A) : *****SLSPAEFFKRNPELAGFPNPARALYQTVRELIENSLDATDVHGILPNIKITIDLIDDARQIYKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQTRG-yGLGVKAAVLYSQ-hQ 
         :                                                                                                                          
 1z5a(A) : KEKFTSLSPAEFFKRNPELAGFPNPARALYQTVRELIENSLDATDVHGILPNIKITIDLIDDARQIYKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQTRGMYGLGVKAAVLYSQMHQ 
           _____________________26________________________________________________________________92____________108________________ 

           ___________________________________________________________________________________________________________233__________ 
 1z59(A) : DKPIEIETSPVNSKRIYTFKLKIDINKNEPIIVERGSVENTRGFHGTSVAISIPGDWPKAKSRIYEYIKRTYIITPYAEFIFKDPEGNVTYYPRLTNKIPKPPQEVKPHPYGVDREEIKI 
         :                                                                                                                          
 1z5a(A) : DKPIEIETSPVNSKRIYTFKLKIDINKNEPIIVERGSVENTRGFHGTSVAISIPGDWPKAKSRIYEYIKRTYIITPYAEFIFKDPEGNVTYYPRLTNKIPKPPQEVKPHPYGVDREEIKI 
           ___________________________________________________________________________________________________________233__________ 

           ____________________________________________________________306___________________________________344___________________ 
 1z59(A) : LINNLKRDYTIKEFLVNEFQSIGDTTADKILELAGLKPNKKVKNLTEEEITRLVETFKKYEDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQGHPFIVEAGVAFGGSIP 
         :                                                                                                                          
 1z5a(A) : LINNLKRDYTIKEFLVNEFQSIGDTTADKILELAGLKPNKKVKNLTEEEITRLVETFKKYEDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQGHPFIVEAGVAFGGSIP 
           ____________________________________________________________306___________________________________344___________________ 

           __________376______________________________________________________________________________________________              
 1z59(A) : VGEEPIVLRYANKIPLIYDEKSDVIWKVVEELDWKRYGIESDQYQvVv--HLCSTKIPYKSAGKESIAEVEDIEKEIKNAL-eVARKLKQYLSEKRKEQEAKKKLLA              
         :                                                                                                                          
 1z5a(A) : VGEEPIVLRYANKIPLIYDEKSDVIWKVVEELDWKRYGIESDQYQMVVMVHLCSTKIPYKSAGKESIAEVEDIEKEIKNALMEVARKLKQYLSEKRKEQEAKKKLL*              
           __________376______________________________________________________________________________________________              

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		18.4
Translation
(A) 		-0.2
Closure
(%) 		99.9
Bending Residues
( green ) 		  26 - 27
  92 - 104
  108 - 112
  233 - 237
  306 - 314
  344 - 349
  376 - 377
  379 - 380
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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