Tyrosine-Protein Kinase Src

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tyrosine-Protein Kinase Src
  Conformer 1
(PDB) 		2src (A)
  Conformer 2
(PDB) 		2oiq (A)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 182 1.65   307 - 324   340 - 516
2 59 1.51   263 - 306   325 - 339

Sequence


           ________________________________________________________________________________________________________________________ 
 2src(A) : TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 
         :                                                                                                                          
 2oiq(A) : ************************************************************************************************************************ 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________________________299_________________319____ 
 2src(A) : IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 
         :                                                                                                                          
 2oiq(A) : ****************************************************AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 
           _____________________________________________________________________________________________299_________________319____ 

           _____________339________________________________________________________________________________________________________ 
 2src(A) : QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 
         :                                                                                                                          
 2oiq(A) : QLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL-------------gAKFPIKWTAPEAALYGRFTIKS 
           _____________339________________________________________________________________________________________________________ 

           __________________________________________________________________________________________                               
 2src(A) : DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ-qPGENL                               
         :                                                                                                                          
 2oiq(A) : DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL                               
           __________________________________________________________________________________________                               

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		20.3
Translation
(A) 		-0.3
Closure
(%) 		94.3
Bending Residues
( green ) 		  299 - 317
  319 - 325
  339 - 341
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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