Tyrosine-Protein Kinase Zap-70

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tyrosine-Protein Kinase Zap-70
  Conformer 1
(PDB) 		1m61 (A)
  Conformer 2
(PDB) 		2oq1 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 43 2.35   114 - 157
2 108 0.44   5 - 113
3 96 0.9   158 - 254

Sequence


           __________________________________________________________________________________________________________106___________ 
 1m61(A) : GSHMPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDC 
         :                                                                                                                          
 2oq1(A) : *****DPAAHLPFFYGSISRAEAEEHLKLAG-aDGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDC 
           __________________________________________________________________________________________________________108___________ 

           __________________________________154___________________________________________________________________________________ 
 1m61(A) : LRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVE 
         :                                                                                                                          
 2oq1(A) : LRDA-vRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHER-pWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVE 
           __________________________________156___________________________________________________________________________________ 

           ___________________                                                                                                      
 1m61(A) : YLKLKADGLIYCLKEACPN                                                                                                      
         :                                                                                                                          
 2oq1(A) : YLKLKADGLIYCLKEACPN                                                                                                      
           ___________________                                                                                                      

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		40.9
Translation
(A) 		-1.6
Closure
(%) 		7.5
Bending Residues
( green ) 		  106 - 114
Bending Region Analysis
Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( yellow ) 		3
Rotation Angle
(deg) 		66.8
Translation
(A) 		-3.0
Closure
(%) 		38.7
Bending Residues
( green ) 		  154 - 159
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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