Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB) 		4hjo (A)
  Conformer 2
(PDB) 		3gop (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 196 0.78   732 - 753   767 - 958
2 50 1.6   681 - 731   754 - 766

Sequence


           ___________________________________________________________________722__________________________751____________766______ 
 4hjo(A) : ***************************LLRILKETEFKKIKVLGSGAFGTVYKGLWIP---vKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFG 
         :                                                                                                                          
 3gop(A) : KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLG----gTVYKGLWIPEGEvKIPVAIMEL------kANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFG 
           ___________________________________________________________________722__________________________751____________766______ 

           ________________________________________________________________________________________________________________________ 
 4hjo(A) : CLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD 
         :                                                                                                                          
 3gop(A) : CLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG------------------vPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________                                 
 4hjo(A) : GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD********************                                 
         :                                                                                                                          
 3gop(A) : GIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDEdSNFYRALMdVVDADEYLI                                 
           ________________________________________________________________________________________                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		27.9
Translation
(A) 		-0.3
Closure
(%) 		72.2
Bending Residues
( green ) 		  722 - 740
  751 - 754
  766 - 770
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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