DynDom - Protein Domain Motions

Pp60 V-Src Tyrosine Kinase Transforming Protein

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pp60 V-Src Tyrosine Kinase Transforming Protein
Conformer 1 (PDB)	1bkl (A)
Conformer 2 (PDB)	2x0s (A)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	48	10.6	51 - 98
2	27	9.13	24 - 50

Sequence

`________________________________________________________________________________________________________________________` `1bkl(A) : **********************************************************************************************************************` `:` `2x0s(A) : VAKKWVYYFGGGNADGNKNMKELLGGKGANLAEMVNLGIPVPPGFTITTEACKTYQETETIPQEVADQVRENVSRVEKEMGAKFGDPANPLLFSVRSGAAASmDTVLNLGLNKVTVDAWV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1bkl(A) : ***********************************************************************EEWYFGKITRRESESLLLNPENPRGTFLVRESETTKGAYCLSVSD` `:` `2x0s(A) : RRAPRLERFVYDSYRRFITMYADIVMQVGREDFEEALSRMKERRGTKFDTDLTASDLKELCDGYLELFELKTGCSFPQDPVMQLFAAIKAVFRSWGNPRATIYRRMNNITGLLGTAVNVQ` `________________________________________________________________________________________________________________________` `_50_____________________________________________________________________________________________________________________` `1bkl(A) : FDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKEFIVTD***************************************************` `:` `2x0s(A) : AMVFGNINDRSATGVAFSRSPSTGENFFFGEYLVNAQGEDVVAGIRTPQQINHSLSLRWAKAHGVGEEERRKRYPSMEEAMPENYRLLCDVRKRLENHYRDMQDLEFTVQDGRLWLLQCR` `247_____________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1bkl(A) : ********************************************************************************************************************` `:` `2x0s(A) : NGKRTIHAAVRIAIDMVNEGLISREEAVLRIDPYQVDHLMHPNLEPGAEKANKPIGRGLAASPGAAVGQVVFDAESAKEWSGRGKKVIMVRLETSPEDLAGMDAACGILTARGGMTSHAA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1bkl(A) : ********************************************************************************************************************` `:` `2x0s(A) : VVARGMGKCCVSGCGDMVIRGKSFKLNGSVFREGDYITIDGSKGLIYAGKLKLRSPDLKGSFQTILQWCQEMKRLGVRTNADTPADAAKARSFGAEGVGLCRTEHMFFEGSRINFIREMI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1bkl(A) : ********************************************************************************************************************` `:` `2x0s(A) : LADSASGRKAALDKLLPIQRADFVGILRAMRGLPVTIRLLDPPLHEFVPHDAAAQFELAQKLGMPAEKVRNRVNALHELNPMLGHRGCRLGITYPEIYNMQVRAIIEAAIAVSEEGSSVI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1bkl(A) : ********************************************************************************************************************` `:` `2x0s(A) : PEIMVPLVGKKEELSLIREEVVKTAEAVITKSGKRVHYTVGTMIEVPRAAVTADSIAQKADFFSFGTNDLTQMGCGFSRDDAGPFLRHYGNLGIYAQDPFQSIDQEGIGELVRIAVTKGR` `________________________________________________________________________________________________________________________` `___________________________________________________________` `1bkl(A) : *********************************************************` `:` `2x0s(A) : RVKPMLKMGICGEHGGDPATIGFCHKVGLDYVSCSPFRVPVAIVAAAHASIKDRRAAMK` `___________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	128.3
Translation (A)	-14.2
Closure (%)	97.4
Bending Residues ( green )	50 - 51
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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