Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		3hqp (J)
  Conformer 2
(PDB) 		2vgb (C)
  Window Length 15
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 374 2.0   8 - 90   181 - 475
2 89 1.26   91 - 180

Sequence


           _________________________________________________________________________________________________________89_____________ 
 3hqp(J) : ***********SQLAHNLTLSI-FDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVGG---DA 
         :                                                                                                                          
 2vgb(C) : QQQQLPAAMADTFLEHLCLLDIDSEPVAA-RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEV 
           ________________________________________________________________________________________________________162_____________ 

           _____________________________________________________________________________179________________________________________ 
 3hqp(J) : VMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQV 
         :                                                                                                                          
 2vgb(C) : ELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG-LVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDV 
           _____________________________________________________________________________254________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(J) : GDVRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYP 
         :                                                                                                                          
 2vgb(C) : AAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(J) : NEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPMSAD--EAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF--DADKLGHDEGKEH 
         :                                                                                                                          
 2vgb(C) : VEAVKMQHAIAREAEAAVYHRQLFEELRRA--APLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADD-VDR 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________                                                                              
 3hqp(J) : RVAAGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                              
         :                                                                                                                          
 2vgb(C) : RVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI*                                                                              
           ___________________________________________                                                                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.6
Translation
(A) 		0.0
Closure
(%) 		89.4
Bending Residues
( green ) 		  89 - 93
  179 - 181
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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