Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB) 		2jiv (B)
  Conformer 2
(PDB) 		3gop (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 179 0.84   766 - 777   796 - 980
2 49 1.1   705 - 745   778 - 790

Sequence


           ___________________________________________________________________745__________________________775____________790______ 
 2jiv(B) : ***********************PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPaNKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFG 
         :                                                                                                                          
 3gop(A) : KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLG----gTVYKGLWIPEGE-vKIPVAIMELk-----ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFG 
           ___________________________________________________________________721__________________________751____________766______ 

           ________________________________________________________________________________________________________________________ 
 2jiv(B) : CLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLgGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL 
         :                                                                                                                          
 3gop(A) : CLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG-------vPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________                                            
 2jiv(B) : EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQ**********************                                            
         :                                                                                                                          
 3gop(A) : EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDEdSNFYRALMdVVDADEYLI                                            
           _____________________________________________________________________________                                            

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		29.2
Translation
(A) 		-1.2
Closure
(%) 		81.4
Bending Residues
( green ) 		  745 - 766
  775 - 782
  790 - 796
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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