DynDom - Protein Domain Motions

Myosin

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin
Conformer 1 (PDB)	1br2 (A)
Conformer 2 (PDB)	1br4 (A)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	575	0.93	37 - 494 517 - 517 519 - 717
2	92	0.73	495 - 516 518 - 518 718 - 786

Sequence

`________________________________________________________________________________________________________________________` `1br2(A) : ******************************LVWVPSEKHGFEAASI------eVTVELQENGKKVTLSKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFC` `:` `1br4(A) : AQKPLSDDEKFLFVDKNFVNNPLAQADWSAKKLVWVPSEKHGFEAASIKEEKGDEVTVELQENGKKVTLSKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFC` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1br2(A) : VVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVAS------gELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIR` `:` `1br4(A) : VVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSpSFSYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1br2(A) : INFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKE---` `:` `1br4(A) : INFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEEEQTSILRVVSSVLQLGNIVFKKERNT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________494_____` `1br2(A) :` `-qASMPDNTAAQKVCHLMGINVTDFTRSILTP----------kAQTKEQADFAIEALAKAKFERLFRWILTRVNKALDaSFLGILDIAGFEIFEINSFEQLCINYTNEKLQQLFNHTMFI` `:` `1br4(A) :` `DQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAIEALAKAKFERLFRWILTRVNKALDaSFLGILDIAGFEIFEINSFEQLCINYTNEKLQQLFNHTMFI` `________________________________________________________________________________________________________________494_____` `______________516_______________________________________________________________________________________________________` `1br2(A) : LEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEEC----aTDTSFVEKLIQEQGNHAKFQKSk-----TEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDK` `:` `1br4(A) : LEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKDKTEFCILHYAGKVTYNASAWLTKNMDPLNDNVTSLLNQSSDK` `______________516_______________________________________________________________________________________________________` `__________________________________________________________________________717___________________________________________` `1br2(A) : FVADLWK---------rTVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKAL` `:` `1br4(A) : FVADLWKDVDRIVGLfRTVGQLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKAL` `__________________________________________________________________________717___________________________________________` `_____________________________________________________________` `1br2(A) : ELDPNLYRIGQSKIFFRTGVLAHLEEERD******************************` `:` `1br4(A) : ELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIIAFQAQCRGYLARKAFAKRQQQLGS` `_____________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.9
Translation (A)	-0.2
Closure (%)	11.1
Bending Residues ( green )	494 - 495 516 - 519 717 - 718
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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