DynDom - Protein Domain Motions

Proto-Oncogene Tyrosine-Protein Kinase Fes/fps

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Proto-Oncogene Tyrosine-Protein Kinase Fes/fps
Conformer 1 (PDB)	3bkb (A)
Conformer 2 (PDB)	3cd3 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	281	0.91	451 - 459 462 - 462 465 - 471 485 - 491 553 - 628 630 - 818
2	63	0.37	460 - 461 463 - 464 472 - 484 492 - 552 629 - 629

Sequence

`___________459_________471__________484_________________________________________________________________552_____________` `3bkb(A) : ***PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGE` `:` `3cd3(A) : SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES---qEYVLSV-----pRHFII----nLYRL----fPSIPLLIDHLLSTQQPL---sGVVLHRAVPKDKWVLNHEDLVLGE` `___________459_________471__________484_________________________________________________________________552_____________` `____________________________________________________________628_________________________________________________________` `3bkb(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA` `:` `3cd3(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCR----pDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA` `____________________________________________________________628_________________________________________________________` `________________________________________________________________________________________________________________________` `3bkb(A) : ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP` `:` `3cd3(A) : ARNCLVTEKNVLKISDFGMSREEADGV-aASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP` `________________________________________________________________________________________________________________________` `________________` `3bkb(A) : SFSTIYQELQSIRKRH` `:` `3cd3(A) : SFSTIYQELQSIRKRH` `________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

Show console

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	6.6
Translation (A)	0.1
Closure (%)	84.2
Bending Residues ( green )	459 - 465 471 - 472 484 - 492 552 - 553 628 - 630
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

Download and extract PyMOL PML script file