Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2c30 (A)
  Conformer 2
(PDB) 		1yhv (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 64 1.08   403 - 454   464 - 471   477 - 480
2 20 0.89   388 - 402   472 - 476
3 196 1.23   455 - 463   484 - 672

Sequence


           _____________400___________________________________________________454______463_____471__476_480________________________ 
 2c30(A) : VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 
         :                                                                                                                          
 1yhv(A) : *SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 
           _____________263___________________________________________________317______326_____334__339_343________________________ 

           ________________________________________________________________________________________________________________________ 
 2c30(A) : TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKR-KlVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 
         :                                                                                                                          
 1yhv(A) : AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________                                                                  
 2c30(A) : HKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLP-ECLVPLIQLY****                                                                  
         :                                                                                                                          
 1yhv(A) : EKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFL-KIAKPLSSLTPLIAAAKEAT                                                                  
           _______________________________________________________                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		14.5
Translation
(A) 		0.2
Closure
(%) 		48.5
Bending Residues
( green ) 		  400 - 404
  471 - 472
  476 - 477
Bending Region Analysis
Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( yellow ) 		3
Rotation Angle
(deg) 		18.6
Translation
(A) 		0.1
Closure
(%) 		60.9
Bending Residues
( green ) 		  454 - 455
  463 - 464
  480 - 484
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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