DynDom - Protein Domain Motions

Transportin-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Transportin-1
Conformer 1 (PDB)	2ot8 (B)
Conformer 2 (PDB)	1qbk (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	657	4.95	140 - 173 185 - 887
2	84	4.63	66 - 139 174 - 184

Sequence

`________________________________________________________________________________________________________________________` `2ot8(B) : *******QGLQQILQLLKESQSPDTTIQRTVQQKLEQLN-----nNYLIFVLTKLK------rSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGE` `:` `1qbk(B) : YEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGE` `________________________________________________________________________________________________________________________` `______________139____________________________173________184_____________________________________________________________` `2ot8(B) : LQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAE------pLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEV` `:` `1qbk(B) : LQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDrPLNI-iPKFLQFFKHSSPKIRSHAVACVNQFIISRTQAL-lHIDSFTENLFALAGDEEPEVRKNVCRALV-lLEV` `______________139____________________________173________184_____________________________________________________________` `________________________________________________________________________________________________________________________` `2ot8(B) : RMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLK-------------------------------------------dTI` `:` `1qbk(B) : RMDRLLPH-hNIVEY-lQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNG-kYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDdDDDDEIDDDDTI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ot8(B) : SDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRIL` `:` `1qbk(B) : SDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGC-qG-iPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPL-tELLKRIL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ot8(B) : DSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQ` `:` `1qbk(B) : DSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQl--pPLIQKWN-lKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ot8(B) : RCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATW` `:` `1qbk(B) : RCVNLVQKTLAQA-lNNAQPDQYEAPDKDF-iVALDLLSGLAEGLGGNIEQLVARSNILTL-yQC-qDK-pEVRQSSFALLGDLTKACFQHVKPCIADF-pILGTNLNPEFISVCNNATW` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ot8(B) : AIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLR` `:` `1qbk(B) : AIGEISIQ-gIE-qPYIP-vLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAP-lQQFIRPWCTSLRNIRDNEEKDSAFRGICT-iSVNPSGVIQDFIFFCDAVASWINPKDDLR` `________________________________________________________________________________________________________________________` `________________________________________` `2ot8(B) : DMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `:` `1qbk(B) : D-fCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	23.6
Translation (A)	0.0
Closure (%)	22.8
Bending Residues ( green )	139 - 148 173 - 174 184 - 185
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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