DynDom - Protein Domain Motions

Importin Subunit Beta-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Subunit Beta-1
Conformer 1 (PDB)	3lww (A)
Conformer 2 (PDB)	3lww (C)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	604	4.33	6 - 455 470 - 496 528 - 543 549 - 562 582 - 589 628 - 630 685 - 686 691 - 704 721 - 756 774 - 796 825 - 835
2	256	2.13	456 - 469 497 - 527 544 - 548 563 - 581 590 - 627 631 - 684 687 - 690 705 - 720 757 - 773 797 - 824 836 - 867

Sequence

`________________________________________________________________________________________________________________________` `3lww(A) : MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE` `:` `3lww(C) : MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3lww(A) : IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN` `:` `3lww(C) : IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3lww(A) : LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE` `:` `3lww(C) : LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________________455_459_____________________` `3lww(A) : DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA` `:` `3lww(C) : DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSA--rVASNVCWAFSSLAEA` `____________________________________________________________________________________________455_459_____________________` `_____________496____________________________527___________541____548__________561_________________581_____589___________` `3lww(A) : AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA` `:` `3lww(C) : AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA` `_____________496____________________________527___________541____548__________561_________________581_____589___________` `________________________627____________________________________________________682_____690___________704_____________720` `3lww(A) : LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI` `:` `3lww(C) : LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI` `________________________627____________________________________________________682_____690___________704_____________720` `_________________________________756______________773____________________796_________________________824________835_____` `3lww(A) : ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR` `:` `3lww(C) : ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR` `_________________________________756______________773____________________796_________________________824________835_____` `_________________________________` `3lww(A) : PMIHELLTEGRRSKTNKAKTLATWATKELRKLK` `:` `3lww(C) : PMIHELLTEGRRSKTNKAKTLATWATKELRKLK` `_________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	12.4
Translation (A)	0.0
Closure (%)	93.4
Bending Residues ( green )	455 - 456 459 - 491 496 - 497 527 - 528 541 - 544 548 - 549 561 - 563 581 - 582 589 - 590 627 - 628 630 - 631 682 - 687 690 - 691 704 - 705 720 - 721 756 - 757 773 - 774 796 - 797 824 - 825 835 - 836
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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