Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase
  Conformer 1
(PDB) 		4ajr (A)
  Conformer 2
(PDB) 		4ajs (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 282 0.69   6 - 14   24 - 31   59 - 99   112 - 314   319 - 324   327 - 334   337 - 340   360 - 362
2 127 1.12   15 - 23   32 - 58   100 - 111   315 - 318   325 - 326   335 - 336   341 - 359   363 - 414

Sequence


           ___________14_______23______31_________________________58_______________________________________99_103__________________ 
 4ajr(A) : ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIMGPLTTPVGGGIRSLNVALRQE 
         :                                                                                                                          
 4ajs(A) : ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIMGPLTTPVGGGIRSLNVALRQE 
           ___________14_______23______31_________________________58_______________________________________99_103__________________ 

           ________________________________________________________________________________________________________________________ 
 4ajr(A) : LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 
         :                                                                                                                          
 4ajs(A) : LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________313__________________334______________________359__ 
 4ajr(A) : KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 
         :                                                                                                                          
 4ajs(A) : KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 
           _____________________________________________________________________313__________________334______________________359__ 

           _______________________________________________________                                                                  
 4ajr(A) : MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM                                                                  
         :                                                                                                                          
 4ajs(A) : MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM                                                                  
           _______________________________________________________                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		7.7
Translation
(A) 		0.3
Closure
(%) 		83.7
Bending Residues
( green ) 		  14 - 15
  23 - 24
  31 - 32
  58 - 61
  99 - 100
  103 - 113
  313 - 327
  334 - 341
  359 - 360
  362 - 363
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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