DynDom - Protein Domain Motions

Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Alpha Subunit
Conformer 1 (PDB)	1bk5 (A)
Conformer 2 (PDB)	1bk6 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	71	0.39	195 - 201 203 - 203 206 - 207 209 - 239 242 - 242 244 - 262 268 - 272 277 - 277 282 - 285
2	103	0.61	92 - 194
3	243	0.48	202 - 202 204 - 205 208 - 208 240 - 241 243 - 243 263 - 267 273 - 276 278 - 281 286 - 508

Sequence

`_______________________________________________________________________________________________________194____201_______` `1bk5(A) : LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYR` `:` `1bk6(A) : LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYR` `_______________________________________________________________________________________________________194____201_______` `____________________________239____________________262__267__272_276__281_285___________________________________________` `1bk5(A) : DYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVT` `:` `1bk6(A) : DYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVT` `____________________________239____________________262__267__272_276__281_285___________________________________________` `________________________________________________________________________________________________________________________` `1bk5(A) : GNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVT` `:` `1bk6(A) : GNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVT` `________________________________________________________________________________________________________________________` `______________________________________________________________` `1bk5(A) : LDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG` `:` `1bk6(A) : LDALENIIKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG` `______________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	7.7
Translation (A)	-0.4
Closure (%)	79.3
Bending Residues ( green )	194 - 196
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	3.9
Translation (A)	0.4
Closure (%)	60.8
Bending Residues ( green )	201 - 209 239 - 244 262 - 263 267 - 268 272 - 273 276 - 278 281 - 282 285 - 286
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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