Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor 2
  Conformer 1
(PDB) 		4xaq (A)
  Conformer 2
(PDB) 		5cnj (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 265 0.44   24 - 186   321 - 442   449 - 451
2 174 0.45   187 - 320   443 - 448   452 - 485

Sequence


           ________________________________________________________________________________________________________________________ 
 4xaq(A) : AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASL-tAITGVIGGSYSDVSIQVANLLRLFQIPQI 
         :                                                                                                                          
 5cnj(A) : AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQI 
           ________________________________________________________________________________________________________________________ 

           ____________________186_________________________________________________________________________________________________ 
 4xaq(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ 
         :                                                                                                                          
 5cnj(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ 
           ____________________186_________________________________________________________________________________________________ 

           __________________________________320___________________________________________________________________________________ 
 4xaq(A) : RLNASFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT 
         :                                                                                                                          
 5cnj(A) : RLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT 
           __________________________________320___________________________________________________________________________________ 

           ____________________________________442___448________________________________________                                    
 4xaq(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPW*                                    
         :                                                                                                                          
 5cnj(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWA                                    
           ____________________________________442___448________________________________________                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		7.7
Translation
(A) 		0.2
Closure
(%) 		99.8
Bending Residues
( green ) 		  186 - 187
  320 - 321
  442 - 444
  448 - 449
  451 - 452
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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