Serine/threonine-Protein Kinase/endoribonuclease Ire1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase/endoribonuclease Ire1
  Conformer 1
(PDB) 		4u6r (A)
  Conformer 2
(PDB) 		7bmk (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 266 1.68   563 - 794   799 - 803   805 - 832   961 - 961
2 133 0.47   795 - 798   804 - 804   833 - 960

Sequence


           ________________________________________________________________________________________________________________________ 
 4u6r(A) : TSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLH 
         :                                                                                                                          
 7bmk(A) : TSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLH 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________________________794_798__ 
 4u6r(A) : SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKH 
         :                                                                                                                          
 7bmk(A) : SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKH 
           _______________________________________________________________________________________________________________794_798__ 

           803__________________________832________________________________________________________________________________________ 
 4u6r(A) : EDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRE 
         :                                                                                                                          
 7bmk(A) : EDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRE 
           803__________________________832________________________________________________________________________________________ 

           _________________________________956__________                                                                           
 4u6r(A) : TLGTLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH***                                                                           
         :                                                                                                                          
 7bmk(A) : TLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPP                                                                           
           _________________________________956__________                                                                           

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		10.9
Translation
(A) 		-0.2
Closure
(%) 		68.9
Bending Residues
( green ) 		  794 - 795
  798 - 799
  803 - 805
  832 - 833
  956 - 961
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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