Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2cdz (A)
  Conformer 2
(PDB) 		1f3m (C)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 178 1.51   366 - 379   398 - 456   480 - 584
2 80 3.32   305 - 365   380 - 397   462 - 464

Sequence


           ________________________________________________________________365_____________________________397_____________________ 
 2cdz(A) : VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA--TVRgKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 
         :                                                                                                                          
 1f3m(C) : *SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 
           ________________________________________________________________314_____________________________346_____________________ 

           ___________________________________456__________________________________________________________________________________ 
 2cdz(A) : AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLH 
         :                                                                                                                          
 1f3m(C) : AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITt------MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE 
           ___________________________________405__________________________________________________________________________________ 

           ______________________________________________________                                                                   
 2cdz(A) : KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT***                                                                   
         :                                                                                                                          
 1f3m(C) : KLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK                                                                   
           ______________________________________________________                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		28.5
Translation
(A) 		-0.7
Closure
(%) 		99.8
Bending Residues
( green ) 		  365 - 380
  397 - 398
  456 - 482
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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