Tyrosine-Protein Kinase Hck

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tyrosine-Protein Kinase Hck
  Conformer 1
(PDB) 		2c0o (A)
  Conformer 2
(PDB) 		2dq7 (X)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 223 1.66   236 - 272   293 - 491
2 23 1.72   233 - 235   273 - 292

Sequence


           ________________________________________________________________________________________________________________________ 
 2c0o(A) : RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 
         :                                                                                                                          
 2dq7(X) : ************************************************************************************************************************ 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________235__________________________________272_________________292______ 
 2c0o(A) : IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVK 
         :                                                                                                                          
 2dq7(X) : ****************************************************KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 
           ________________________________________________________5___________________________________42__________________62______ 

           ________________________________________________________________________________________________________________________ 
 2c0o(A) : LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI------------pIKWTAPEAINFGSFTIKSDV 
         :                                                                                                                          
 2dq7(X) : LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEtARQGAKFPIKWTAPEAALYGRFTIKSDV 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________________                                    
 2c0o(A) : WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQeEIP                                    
         :                                                                                                                          
 2dq7(X) : WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY***********                                    
           _____________________________________________________________________________________                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		25.9
Translation
(A) 		-1.1
Closure
(%) 		55.3
Bending Residues
( green ) 		  235 - 236
  272 - 273
  292 - 293
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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