DynDom - Protein Domain Motions

Vitamin D Hydroxylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Vitamin D Hydroxylase
Conformer 1 (PDB)	3a50 (B)
Conformer 2 (PDB)	3a4h (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	317	0.88	6 - 98 101 - 102 107 - 149 198 - 200 221 - 235 241 - 401
2	70	2.07	99 - 100 103 - 106 150 - 197 201 - 211 236 - 240

Sequence

`_______________________________________________________________________________________________98_____106_______________` `3a50(B) : ALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `:` `3a4h(A) : **TTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `_______________________________________________________________________________________________98_____106_______________` `_________________________149_____________________________________________197__________210__________________231______240_` `3a50(B) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETT` `:` `3a4h(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETT` `_________________________149_____________________________________________197__________210__________________231______240_` `________________________________________________________________________________________________________________________` `3a50(B) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `:` `3a4h(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `________________________________________________________________________________________________________________________` `__________________________________________` `3a50(B) : GRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPRSA` `:` `3a4h(A) : GRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA` `__________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	14.3
Translation (A)	-0.8
Closure (%)	25.1
Bending Residues ( green )	98 - 103 106 - 112 149 - 150 197 - 198 200 - 201 210 - 227 231 - 236 240 - 241
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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