Camp-Specific 3',5'-Cyclic Phosphodiesterase 4B

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Camp-Specific 3',5'-Cyclic Phosphodiesterase 4B
  Conformer 1
(PDB)
1xot (A)
  Conformer 2
(PDB)
1f0j (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 279 0.75   166 - 282   284 - 284   294 - 295   302 - 406   428 - 482
2 37 0.52   283 - 283   285 - 293   296 - 301   407 - 427

Sequence


           ________________________________________________________________________________________________________________________ 
 1xot(A) : ***********EDHLAKELEDLNKWGLNIFNVAGYSHNRPLT-iMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA 
         :                                                                                                                          
 1f0j(B) : SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA 
           ________________________________________________________________________________________________________________________ 

           ________282________293_____301__________________________________________________________________________________________ 
 1xot(A) : AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 
         :                                                                                                                          
 1f0j(B) : AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 
           ________282________293_____301__________________________________________________________________________________________ 

           ____________406__________________427_____________________________________________________________                        
 1xot(A) : DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIP***                        
         :                                                                                                                          
 1f0j(B) : DLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQAP                        
           ____________406__________________427_____________________________________________________________                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.4
Translation
(A)
-0.1
Closure
(%)
91.9
Bending Residues
( green )
  282 - 285
  293 - 296
  301 - 302
  406 - 407
  427 - 442
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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