Focal Adhesion Kinase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Focal Adhesion Kinase 1
  Conformer 1
(PDB)
2aeh (B)
  Conformer 2
(PDB)
2al6 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 254 1.07   35 - 156   169 - 171   173 - 177   187 - 191   225 - 229   235 - 239   241 - 242   255 - 361
2 73 0.7   157 - 168   172 - 172   178 - 186   192 - 224   230 - 234   240 - 240   243 - 254

Sequence


           ________________________________________________________________________________________________________________________ 
 2aeh(B) : MERVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVK 
         :                                                                                                                          
 2al6(B) : MERVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYGLRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVK 
           ________________________________________________________________________________________________________________________ 

           _156_________168______177___183_____191______________________________224__229__234__239____________254__________________ 
 2aeh(B) : NDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVEL 
         :                                                                                                                          
 2al6(B) : NDYMLEIADQVDQEIALKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVEL 
           _156_________168______177___183_____191______________________________224__229__234__239____________254__________________ 

           _______________________________________________________________________________________________________________          
 2aeh(B) : AIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQ********************          
         :                                                                                                                          
 2al6(B) : AIGPEEGISYLTDKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKtDDYAEII          
           _______________________________________________________________________________________________________________          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
8.6
Translation
(A)
0.0
Closure
(%)
19.5
Bending Residues
( green )
  156 - 157
  168 - 169
  171 - 173
  177 - 178
  183 - 187
  191 - 192
  224 - 225
  229 - 230
  234 - 235
  239 - 243
  254 - 255
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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