Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB) 		2itz (A)
  Conformer 2
(PDB) 		5uga (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 247 1.68   706 - 748   769 - 982
2 20 3.13   749 - 768

Sequence


           ______________________________________________745____________________768________________________________________________ 
 2itz(A) : EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN 
         :                                                                                                                          
 5uga(A) : ******LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLN 
           ______________________________________________745____________________768________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2itz(A) : WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAE----------vPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 
         :                                                                                                                          
 5uga(A) : WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________                                                 
 2itz(A) : PICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPmDEEDMDDVVDADEYLIP                                                 
         :                                                                                                                          
 5uga(A) : PICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDE***********************                                                 
           ________________________________________________________________________                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		56.4
Translation
(A) 		-1.6
Closure
(%) 		40.4
Bending Residues
( green ) 		  745 - 749
  768 - 771
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download