Erythropoietin Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Erythropoietin Receptor
  Conformer 1
(PDB)
1eer (B)
  Conformer 2
(PDB)
1ebp (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 106 1.68   21 - 120   157 - 157   171 - 171   206 - 209
2 92 1.37   121 - 156   158 - 170   172 - 205   210 - 218

Sequence


           ______________________________________________________________________________________________________________120_______ 
 1eer(B) : DPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGQYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGL 
         :                                                                                                                          
 1ebp(B) : **KFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGL 
           ______________________________________________________________________________________________________________120_______ 

           __________________________156___________170________________________________205_209___________                            
 1eer(B) : VARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGQGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSEWSEPVSLLT                            
         :                                                                                                                          
 1ebp(B) : VARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLT                            
           __________________________156___________170________________________________205_209___________                            

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
19.6
Translation
(A)
0.2
Closure
(%)
95.3
Bending Residues
( green )
  120 - 121
  156 - 158
  170 - 172
  205 - 206
  209 - 210
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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