Hyaluronidase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Hyaluronidase
  Conformer 1
(PDB)
2cbi (B)
  Conformer 2
(PDB)
2j62 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 453 0.49   43 - 216   239 - 254   291 - 291   335 - 340   364 - 388   392 - 622
2 127 0.86   217 - 238   255 - 290   292 - 334   341 - 363   389 - 391

Sequence


           ________________________________________________________________________________________________________________________ 
 2cbi(B) : *VLVPNLNPTPENLEVVGDGFKITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGEVDDDIPELDEALNGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTF 
         :                                                                                                                          
 2j62(B) : QVLVPNLNPTPENLEVVGDGFKITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGEVDDDIPELDEALNGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTF 
           ________________________________________________________________________________________________________________________ 

           ____________________________________________________214____________229______________________254_________________________ 
 2cbi(B) : KQLVKESNIPEVNITDYPTVSARGIVEGFYGTPWTHQDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPESEMQRMQELINASAENKVDFVFGISPGIDIRFDGDAGEEDFNHLIT 
         :                                                                                                                          
 2j62(B) : KQLVKESNIPEVNITDYPTVSARGIVEGFYGTPWTHQDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPESEMQRMQELINASAENKVDFVFGISPGIDIRFDGDAGEEDFNHLIT 
           ____________________________________________________214____________229______________________254_________________________ 

           ________290_________________________________________334___340____________________363______________________388___________ 
 2cbi(B) : KAESLYDMGVRSFAIYWDDIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRAYTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYNRNMAVWWNYPV 
         :                                                                                                                          
 2j62(B) : KAESLYDMGVRSFAIYWDDIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRAYTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYDRNMAVWWNYPV 
           ________290_________________________________________334___340____________________363______________________388___________ 

           ________________________________________________________________________________________________________________________ 
 2cbi(B) : TDYFKGKLALGPMHGLDKGLNQYVDFFTVNPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFANHSTRMDNKTWAKSGREDAPELRAKMDELWNKLSSKEDAS 
         :                                                                                                                          
 2j62(B) : TDYFKGKLALGPMHGLDKGLNQYVDFFTVNPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFANHSTRMDNKTWAKSGREDAPELRAKMDELWNKLSSKEDAS 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________________________________                
 2cbi(B) : ALIEELYGEFARMEEACNNLKANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKEIAQNKLNTALSSFAVISEKVAQSFIQEALSFDLTLI                
         :                                                                                                                          
 2j62(B) : ALIEELYGEFARMEEACNNLKANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKEIAQNKLNTALSSFAVISEKVAQSFIQEALSFDLTLI                
           _________________________________________________________________________________________________________                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
6.8
Translation
(A)
-0.2
Closure
(%)
80.5
Bending Residues
( green )
  214 - 221
  229 - 242
  254 - 255
  290 - 292
  334 - 335
  340 - 341
  363 - 364
  388 - 389
  391 - 392
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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