3-Isopropylmalate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 3-Isopropylmalate Dehydrogenase
  Conformer 1
(PDB) 		1hex (A)
  Conformer 2
(PDB) 		1a05 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 187 1.89   3 - 101   111 - 115   254 - 260   267 - 342
2 153 1.16   102 - 110   116 - 253   261 - 266

Sequence


           ___________________________________________________________________________________________________101______110__115____ 
 1hex(A) : *MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 
         :                                                                                                                          
 1a05(A) : MKKIAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDASDDPLPAASLQLAMAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFPQLLDASPLR 
           ___________________________________________________________________________________________________102______111__116____ 

           ________________________________________________________________________________________________________________________ 
 1hex(A) : EEIARGVDVLIVRELTGGIYFGEPRGM----SEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVT 
         :                                                                                                                          
 1a05(A) : PELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQGRRKQLCSVDKANVLETTRLWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLLT 
           ________________________________________________________________________________________________________________________ 

           _______________253____260____________________________________________________________________________________________    
 1hex(A) : GNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKAL---LETPPPDLGGSA--GTEAFTATVLRHLA**    
         :                                                                                                                          
 1a05(A) : GNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHSLNAEPWAQRVEAAVQRVLDQGLRTADIAAPGTPVIGTKAMGAAVVNALNLK    
           _______________258____265____________________________________________________________________________________________    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		22.5
Translation
(A) 		-0.1
Closure
(%) 		94.5
Bending Residues
( green ) 		  101 - 103
  110 - 111
  115 - 116
  253 - 254
  260 - 267
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download