Anti-Hiv-1 Antibody 2F5 Heavy Chain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Anti-Hiv-1 Antibody 2F5 Heavy Chain
  Conformer 1
(PDB)
1tji (H)
  Conformer 2
(PDB)
2p8m (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 120 0.42   4 - 113
2 91 0.45   114 - 210

Sequence


           ________________________________________________________________________________________________________________________ 
 1tji(H) : RITLKESGPPLVKPTQTLTLTCSFSGFSLSDFGVGVGWIRQPPGKALEWLAIIYSDDDKRYSPSLNTRLTITKDTSKNQVVLVMTRVSPVDTATYFCAHRRGPTTLFGVPIARGPVNAMD 
         :                                                                                                                          
 2p8m(B) : RITLKESGPPLVKPTQTLTLTCSFSGFSLSDFGVGVGWIRQPPGKALEWLAIIYSDDDKRYSPSLNTRLTITKDTSKNQVVLVMTRVSPVDTATYFCAHRRGPT---------gPVNAMD 
           ________________________________________________________________________________________________________________________ 

           ______110___________________________________________________________________________________________________________     
 1tji(H) : VWGQGITVTISSTSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSdK     
         :                                                                                                                          
 2p8m(B) : VWGQGITVTISSTSTKGPSVFPLAPS------gTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVEP****     
           ______110___________________________________________________________________________________________________________     

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
4.4
Translation
(A)
-0.8
Closure
(%)
55.7
Bending Residues
( green )
  110 - 116
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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