Beta-Secretase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Beta-Secretase
  Conformer 1
(PDB)
1sgz (A)
  Conformer 2
(PDB)
2g94 (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 356 0.35   2 - 64   79 - 105   115 - 380
2 23 0.74   65 - 78   106 - 114

Sequence


           _________________________________________________________________63_____________78________________________105______114__ 
 1sgz(A) : GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
         :                                                                                                                          
 2g94(A) : GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
           _________________________________________________________________63_____________78________________________105______114__ 

           ________________________________________________________________________________________________________________________ 
 1sgz(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
         :                                                                                                                          
 2g94(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1sgz(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
         :                                                                                                                          
 2g94(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
           ________________________________________________________________________________________________________________________ 

           _____________________________                                                                                            
 1sgz(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
         :                                                                                                                          
 2g94(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
           _____________________________                                                                                            

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
12.3
Translation
(A)
-0.2
Closure
(%)
89.4
Bending Residues
( green )
  63 - 65
  78 - 79
  105 - 106
  114 - 118
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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