DynDom - Protein Domain Motions

Dual Oxidase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Dual Oxidase 1
Conformer 1 (PDB)	7d3e (A)
Conformer 2 (PDB)	7d3f (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	1305	2.47	24 - 847 923 - 1549
2	51	4.09	848 - 922

Sequence

`________________________________________________________________________________________________________________________` `7d3e(A) : QNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGD` `:` `7d3f(A) : QNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : VVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQ` `:` `7d3f(A) : VVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : RLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDV` `:` `7d3f(A) : RLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : DALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIV` `:` `7d3f(A) : DALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : LEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLgM` `:` `7d3f(A) : LEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARL-m` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : EALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPvNFVLSrTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESiQEWELREQELMRAAVTREQRRHLLETFFRHLFSQV` `:` `7d3f(A) : EALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPvNFVLSrTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESiQEWELREQELMRAAVTREQRRHLLETFFRHLFSQV` `________________________________________________________________________________________________________________________` `_____________________________________________________835________________________________________________________________` `7d3e(A) : LDINQADAGTLsQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLAD----gYLSFREFLDILVVFM----eEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEV` `:` `7d3f(A) : L----------sQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFI--------kAQLAEV` `_____________________________________________________835________________________________________________________________` `____917_________________________________________________________________________________________________________________` `7d3e(A) : VES-MFwEDFHFMLRlLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETF` `:` `7d3f(A) : VESeLTWEDFHFML-lLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETF` `____917_________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : LNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLI` `:` `7d3f(A) : LNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : IHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTyP` `:` `7d3f(A) : IHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTyP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7d3e(A) : KLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRS` `:` `7d3f(A) : KLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRS` `________________________________________________________________________________________________________________________` `_____________________________________________________________________` `7d3e(A) : LFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF` `:` `7d3f(A) : LFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF` `_____________________________________________________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	91.8
Translation (A)	-3.0
Closure (%)	68.7
Bending Residues ( green )	835 - 848 917 - 1013
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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