DynDom - Protein Domain Motions

Hepatocyte Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Hepatocyte Growth Factor Receptor
Conformer 1 (PDB)	1shy (B)
Conformer 2 (PDB)	2uzx (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	411	1.13	44 - 519
2	43	0.72	520 - 562

Sequence

`________________________________________________________________________________________________________________________` `1shy(B) : KYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVH` `:` `2uzx(B) : qLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLE-------------------vWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNH-----sEVH` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1shy(B) : CIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRII` `:` `2uzx(B) : CIFS----ePSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSY----pLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRII` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1shy(B) : RFCSINSGLHSYMEMPLECILTkEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKInVRCLQHFYGPNHEHCFNRdEYRTEFTTALQ` `:` `2uzx(B) : RFCSINSGLHSYMEMPLECILTkEVFNILQAAYVSKPGAQLARQIGASLNDDILFAVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKInVRCLQHFYGPN-------dEYRTEFTTALQ` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________515______________________________` `1shy(B) : RVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKC` `:` `2uzx(B) : RVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKC` `_______________________________________________________________________________________515______________________________` `___________________________________________________________________________________________________________` `1shy(B) : VRSEECLSGTWTQQICLPA**************************************************************************************` `:` `2uzx(B) : VRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPfNMSIIISNGHGTTQYSTFSYVDP` `___________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	62.0
Translation (A)	-0.6
Closure (%)	84.7
Bending Residues ( green )	515 - 520
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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