Hyaluronate Lyase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Hyaluronate Lyase
  Conformer 1
(PDB) 		1egu (A)
  Conformer 2
(PDB) 		1f1s (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 498 1.52   181 - 186   378 - 419   430 - 485   487 - 487   492 - 885
2 214 1.06   173 - 180   187 - 377   420 - 429   486 - 486   488 - 491

Sequence


           _____________________________________________________________________________________180___186__________________________ 
 1egu(A) : ******************************************************************************KDTYTDRLDDWNGIIAGNQYYDSKNDQMAKLNQELEGKVADS 
         :                                                                                                                          
 1f1s(A) : SEHPQPVTTQIEKSVNTALNKNYVFNKADYQYTLTNPSLGKIVGGILYPNATGSTTVKISDKSGKIIKEVPLSVTASTEDNFTKLLDKWNDVTIGNYVYDTNDSNMQKLNQKLDETNAKN 
           _____________________________________________________________________________________258___264__________________________ 

           ________________________________________________________________________________________________________________________ 
 1egu(A) : LSSISSQADRIYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKHVYNSEKSIVG--NWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVP 
         :                                                                                                                          
 1f1s(A) : IEAIKLDSNRTFLWKDLDNLNNSAQLTATYRRLEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYNVNKDIEGSANWWDFEIGVPRSITGTLSLMNNYFTDAEIKTYTDPIEHFVP 
           ________________________________________________________________________________________________________________________ 

           ____________________________________________377_______________________________________419_______429_____________________ 
 1egu(A) : DPEHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAPLL 
         :                                                                                                                          
 1f1s(A) : DAEYFRKTLVNPFKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAEGFYADGSYIDHTNVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYKWINQSFLPLI 
           ____________________________________________457_______________________________________499_______509_____________________ 

           ________________________________485_____________________________________________________________________________________ 
 1egu(A) : VNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQSDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGFGLSLFS 
         :                                                                                                                          
 1f1s(A) : VKGELMDMSRGRSISREAASSHAAAVEVLRGFLRLANMSNEERNLDLKSTIKTIITSNKFYNVFNNLKSYSDIANMNKLLNDSTVATKPLKSNLSTFNSMDRLAYYNAKKDFGFALSLHS 
           ________________________________565_____________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1egu(A) : SRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTETDAKRADSD--------------TGKVL-PSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKD 
         :                                                                                                                          
 1f1s(A) : KRTLNYEGMNDENTRGWYTGDGMFYIYNSDQSHYSNHFWPTVNPYKMAGTTEKDAKREDTTKEFMSKHSKDAKEKTGQVTGTSDFVGSVKLNDHFALAAMDFTNWDRTLTAQKGWVILND 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1egu(A) : KIAFLGSNIQNTS-TDTAATTIDQRKLESSNPYKVYVNDKEASLTE-QEKDYPETQSVFLESSDSKKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKE-VENEFLTISQAHKQNGDS 
         :                                                                                                                          
 1f1s(A) : KIVFLGSNIKNTNGIGNVSTTIDQRKDDSKTPYTTYVNGKTIDLKQASSQQFTDTKSVFLESKEPGRNIGYIFFKNSTIDIERKEQTGTWNSINRTSKNTSIVSNPFITISQKHDNKGDS 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________________________________                      
 1egu(A) : YGYMLIPNVDRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVLKRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKqH                      
         :                                                                                                                          
 1f1s(A) : YGYMMVPNIDRTSFDKLANSKEVELLENSSKQQVIYDKNSQTWAVIKHDNQESLINNQFKMNKAGLYLVQKVGNDYQNVYYQPQTM-TKTDQLAI****                      
           ___________________________________________________________________________________________________                      

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.1
Translation
(A) 		-0.3
Closure
(%) 		75.0
Bending Residues
( green ) 		  180 - 181
  186 - 187
  377 - 378
  419 - 420
  429 - 430
  485 - 492
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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