Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin-Like Growth Factor 1 Receptor
  Conformer 1
(PDB)
7u23 (E)
  Conformer 2
(PDB)
7v3p (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 158 1.04   300 - 457
2 268 1.17   3 - 299
3 230 10.79   461 - 796

Sequence


           ________________________________________________________________________________________________________________________ 
 7u23(E) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-----rSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLC 
         :                                                                                                                          
 7v3p(A) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLC 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 7u23(E) : YLSTVDWSLILDAVSNNYIVGNKPPKECGDLCP---cEKTTINNEYNYRCWTTNRCQKMCPSTC---aCTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR 
         :                                                                                                                          
 7v3p(A) : YLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTmCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWR 
           ________________________________________________________________________________________________________________________ 

           _____________________________________292________________________________________________________________________________ 
 7u23(E) : CVDRDFCANILeGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFL 
         :                                                                                                                          
 7v3p(A) : CVDRDFCANIL-SfVIHDGECMQECPSGFIRNGSQSMYCIP-----pKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFL 
           _____________________________________292________________________________________________________________________________ 

           ________________________________________________________________________________455_____________________________________ 
 7u23(E) : KNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLIS 
         :                                                                                                                          
 7v3p(A) : KNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLIS 
           ________________________________________________________________________________455_____________________________________ 

           ________________________________________________________________________________________________________________________ 
 7u23(E) : FTVYYKEAPFKNVTEYD--sWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRW 
         :                                                                                                                          
 7v3p(A) : FTVYYKEAPFKNVTEYDGQsWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRW 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 7u23(E) : QRQPQD--------------------------------eEAEYRKVFENFLHNSIFVPRPyPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPA****** 
         :                                                                                                                          
 7v3p(A) : QRQPQDGYLYRHNYCSKDKIPIRKcACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPReYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDI 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________________________                            
 7u23(E) : *********************************************************************************************                            
         :                                                                                                                          
 7v3p(A) : PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK                            
           _____________________________________________________________________________________________                            

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
65.1
Translation
(A)
2.4
Closure
(%)
96.3
Bending Residues
( green )
  292 - 300
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
85.3
Translation
(A)
-3.7
Closure
(%)
74.1
Bending Residues
( green )
  455 - 461
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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