Nad-Dependent Deacetylase Sirtuin-3, Mitochondrial

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Deacetylase Sirtuin-3, Mitochondrial
  Conformer 1
(PDB) 		3gls (F)
  Conformer 2
(PDB) 		3glr (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 163 0.61   125 - 152   205 - 246   300 - 392
2 105 0.89   153 - 204   247 - 299

Sequence


           _____________________________152_________________________________________________204____________________________________ 
 3gls(F) : **LSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 
         :                                                                                                                          
 3glr(A) : GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 
           _____________________________152_________________________________________________204____________________________________ 

           ___246_________________________________________________298______________________________________________________________ 
 3gls(F) : ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV 
         :                                                                                                                          
 3glr(A) : ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV 
           ___246_________________________________________________298______________________________________________________________ 

           __________________________________                                                                                       
 3gls(F) : AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKL                                                                                       
         :                                                                                                                          
 3glr(A) : AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKL                                                                                       
           __________________________________                                                                                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.8
Translation
(A) 		0.1
Closure
(%) 		90.5
Bending Residues
( green ) 		  152 - 153
  204 - 209
  246 - 247
  298 - 300
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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