Nad-Dependent Deacetylase Sirtuin-5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Deacetylase Sirtuin-5
  Conformer 1
(PDB) 		2b4y (A)
  Conformer 2
(PDB) 		3riy (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 149 0.31   38 - 65   110 - 159   228 - 300
2 104 0.79   66 - 108   160 - 227

Sequence


           _________________________________65________________________________________108__________________________________________ 
 2b4y(A) : *****PSSS-aDFRKFFAKAKHIVIISGAGVSAESGV-------gYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREV-gSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG 
         :                                                                                                                          
 3riy(A) : SFTARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG 
           _________________________________65________________________________________108__________________________________________ 

           _____158__________________________________________________________________227___________________________________________ 
 2b4y(A) : TKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAA-fAPQVAARGVP 
         :                                                                                                                          
 3riy(A) : TKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVP 
           _____158__________________________________________________________________227___________________________________________ 

           ________________________________                                                                                         
 2b4y(A) : VAEFNTETTPATNRFRFHFQGPCGTTLPEALA                                                                                         
         :                                                                                                                          
 3riy(A) : VAEFNTETTPATNRFRFHFQGPCGTTLPEALA                                                                                         
           ________________________________                                                                                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.6
Translation
(A) 		0.3
Closure
(%) 		88.4
Bending Residues
( green ) 		  65 - 66
  108 - 112
  158 - 160
  227 - 229
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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