DynDom - Protein Domain Motions

Potassium-Transporting Atpase Alpha Chain 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Potassium-Transporting Atpase Alpha Chain 1
Conformer 1 (PDB)	2xzb (A)
Conformer 2 (PDB)	2yn9 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	74	2.2	121 - 144 290 - 337 341 - 342
2	40	1.12	95 - 120 145 - 158
3	151	1.01	50 - 88 178 - 289
4	278	0.67	338 - 340 343 - 353 368 - 369 371 - 371 374 - 378 776 - 1031
5	414	0.89	354 - 367 370 - 370 372 - 373 379 - 775

Sequence

`______________________________________________88_____________________________120_____________________144________155_____` `2xzb(A) : *******MEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQE` `:` `2yn9(A) : LENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQE` `______________________________________________88_____________________________120_____________________144________155_____` `___________________________________________________________________________________________________________________278__` `2xzb(A) :` `---------------qQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIA` `:` `2yn9(A) :` `FKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIA` `___________________________________________________________________________________________________________________278__` `___________________________________________________334________________353___________367_________________________________` `2xzb(A) : SLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHL` `:` `2yn9(A) : SLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHL` `___________________________________________________334________________353___________367_________________________________` `________________________________________________________________________________________________________________________` `2xzb(A) : WFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAP` `:` `2yn9(A) : WFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2xzb(A) : ERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASV` `:` `2yn9(A) : ERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2xzb(A) : GIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILL` `:` `2yn9(A) : GIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILL` `________________________________________________________________________________________________________________________` `__________773___________________________________________________________________________________________________________` `2xzb(A) : DDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFT` `:` `2yn9(A) : DDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFT` `__________773___________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2xzb(A) : AMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLV` `:` `2yn9(A) : AMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLV` `________________________________________________________________________________________________________________________` `_________________________________` `2xzb(A) : PMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY` `:` `2yn9(A) : PMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY` `_________________________________`

Morph

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Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	15.6	0.4	99.9	120 - 121 144 - 145	Bending Region Analysis
1	3	19.0	-2.1	9.2	278 - 291	Bending Region Analysis
1	4	9.1	-1.6	99.8	334 - 347	Bending Region Analysis
3	2	27.2	-1.5	43.1	88 - 96 155 - 179	Bending Region Analysis
4	5	6.1	-0.6	1.0	353 - 354 367 - 379 773 - 780	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 4 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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