Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11
  Conformer 1
(PDB) 		5u6p (A)
  Conformer 2
(PDB) 		5u6o (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 388 0.76   103 - 494   557 - 558   561 - 565
2 53 0.83   495 - 541   553 - 556   559 - 560
3 23 0.94   543 - 546   566 - 584

Sequence


           ________________________________________________________________________________________________________________________ 
 5u6p(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNsSEIILDPKVIKM 
         :                                                                                                                          
 5u6o(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNsSEIILDPKVIKM 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5u6p(A) : NYLKSWFVVDFISSIPVDYIFLIVEKGrALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQ 
         :                                                                                                                          
 5u6o(A) : NYLKSWFVVDFISSIPVDYIFLIVEKGrALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5u6p(A) : YSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNF 
         :                                                                                                                          
 5u6o(A) : YSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNF 
           ________________________________________________________________________________________________________________________ 

           ___________________________494____________________________________________541____________556______565___________________ 
 5u6p(A) : NCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 
         :                                                                                                                          
 5u6o(A) : NCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 
           ___________________________494____________________________________________541____________556______565___________________ 

           ________________________                                                                                                 
 5u6p(A) : TVAIDRLDRIGKKNSILLQKFQKD                                                                                                 
         :                                                                                                                          
 5u6o(A) : TV**********************                                                                                                 
           ________________________                                                                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 8.7 0.6 45.1   494 - 495   556 - 561 Bending Region Analysis
1 3 17.3 0.4 28.4   565 - 566 Bending Region Analysis
3 2 24.2 0.2 96.5   541 - 553 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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