DynDom - Protein Domain Motions

Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 11
Conformer 1 (PDB)	5u6o (A)
Conformer 2 (PDB)	6uqf (A)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	438	2.53	97 - 254 265 - 266 293 - 583
2	36	4.34	255 - 264 267 - 292

Sequence

`________________________________________________________________________________________________________________________` `5u6o(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVN--sSEIILDPKVI` `:` `6uqf(A) : MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMNFRTGTVNEDSSEIILDPKVI` `________________________________________________________________________________________________________________________` `___________________235_________________264_________________________292__________________________________________________` `5u6o(A) : KMNYLKSWFVVDFISSIPVDYIFLIVEKGrALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWG` `:` `6uqf(A) : KMNYLKSWFVVDFISSIPVDYIFLIVE--rALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWG` `___________________235_________________264_________________________292__________________________________________________` `________________________________________________________________________________________________________________________` `5u6o(A) : KQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIV` `:` `6uqf(A) : KQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5u6o(A) : NFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA` `:` `6uqf(A) : NFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA` `________________________________________________________________________________________________________________________` `_____________________________________________________` `5u6o(A) : FETV*************************************************` `:` `6uqf(A) : FETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQA` `_____________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	19.3
Translation (A)	-1.8
Closure (%)	99.5
Bending Residues ( green )	235 - 255 264 - 268 292 - 302
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Chart image not calculated - the graph is too big to count connection types.

PyMOL Script

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