DynDom - Protein Domain Motions

Probable Aspartokinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Probable Aspartokinase
Conformer 1 (PDB)	2hmf (A)
Conformer 2 (PDB)	3c20 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	303	1.05	4 - 235 248 - 298 411 - 421 440 - 448
2	149	1.74	236 - 247 307 - 410 422 - 439 449 - 468

Sequence

`________________________________________________________________________________________________________________________` `2hmf(A) : TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKS` `:` `3c20(B) : TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKS` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________________235______` `2hmf(A) : RDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPR` `:` `3c20(B) : RDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPR` `_______________________________________________________________________________________________________________235______` `___247________________________________________________298_______________________________________________________________` `2hmf(A) : LVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNI` `:` `3c20(B) : LVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNI` `___247________________________________________________298_______________________________________________________________` `___________________________________________410________421_______________439______448______________________` `2hmf(A) : SLVVSEEDVDKALKALKREFGD--fLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK` `:` `3c20(B) : SLVVSEEDVDKALKALKREFGDkSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK` `___________________________________________410________421_______________439______448______________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.0
Translation (A)	0.7
Closure (%)	58.6
Bending Residues ( green )	235 - 236 247 - 248 298 - 307 410 - 418 421 - 422 439 - 440 448 - 449
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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