Protein Piwi

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Protein Piwi
  Conformer 1
(PDB) 		6kr6 (A)
  Conformer 2
(PDB) 		5guh (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 616 2.75   95 - 262   370 - 841
2 85 2.39   263 - 369

Sequence


           ________________________________________________________________________________________________________________________ 
 6kr6(A) : *****************DGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIE-YKISIKFVGFISCAEPRFL 
         :                                                                                                                          
 5guh(A) : ISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEEDSTGVRKALMRVHSKTLG-GYLFDGTVLYTVNRLHPDPMELYSDRKTDNERMRILIKLTCEVSPGDYHYI 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________262____________________________________________________ 
 6kr6(A) : QVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVMRTETIYDIMRRCSdEVRV---NVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCK 
         :                                                                                                                          
 5guh(A) : QIFNIIIRKCFNLLKLQLMGRDYFDPEAKIDIPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATKkIFLEDVVGKIVMTDYNKRTYRVDDVA-nVSPKSTFKMR 
           _________________________________________________________________316____________________________________________________ 

           ________________________________________________369_____________________________________________________________________ 
 6kr6(A) : GRDISFVEYYLTKYNIRIRDHNQPLLIS--------------vVLIPELCR---------VnFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRII 
         :                                                                                                                          
 5guh(A) : DENITYIEYYYKKYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRANFKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKELVKIKGRQL 
           ________________________________________________424_____________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 6kr6(A) : GQQNIVFHNG-KVPAGENAD-WQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCV-RSDPKLILCLVPNDNAERYSSIK 
         :                                                                                                                          
 5guh(A) : PPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQ--LNSWVVITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEEVIARKNPALILCVLARNYADRYEAIK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 6kr6(A) : KRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQNSTYFSTVT-ECaNTLWPMIAKALRQYQHEHRKLPSRI 
         :                                                                                                                          
 5guh(A) : KKCTVDRAVPTQVVCARNMSSKSAMSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAFVATLD-KQMTQYYSIVNAHlSSHMGFNIASAVKKFREKNGTYPARI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 6kr6(A) : VFYRDGVgS--LKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFL----NGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYK 
         :                                                                                                                          
 5guh(A) : FIYRDGVGDGQIPYVHSHEVAEIKKKLAEIYAGVEI---KLAFIIVSKRINTRIFVQRGRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTGLNPDRIQRLTYK 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________                                                                          
 6kr6(A) : MCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLHSIPQNALEKKFYYL                                                                          
         :                                                                                                                          
 5guh(A) : LTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHYSLNETLYFL                                                                          
           _______________________________________________                                                                          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		38.6
Translation
(A) 		-3.1
Closure
(%) 		83.7
Bending Residues
( green ) 		  262 - 263
  369 - 370
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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