Proto-Oncogene Tyrosine-Protein Kinase Abl1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Abl1
  Conformer 1
(PDB) 		2hyy (B)
  Conformer 2
(PDB) 		2fo0 (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 237 1.03   237 - 379   400 - 494
2 20 5.41   380 - 399

Sequence


           ________________________________________________________________________________________________________________________ 
 2hyy(B) : ************************************************************************************************************************ 
         :                                                                                                                          
 2fo0(A) : ARWNkENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2hyy(B) : ******************************************************************DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE-tMEVEEFLKE 
         :                                                                                                                          
 2fo0(A) : YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________377___________________399_______ 
 2hyy(B) : AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 
         :                                                                                                                          
 2fo0(A) : AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 
           ________________________________________________________________________________________396___________________418_______ 

           _________________________________________________________________________________________________________                
 2hyy(B) : APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ*************                
         :                                                                                                                          
 2fo0(A) : APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG                
           _________________________________________________________________________________________________________                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		139.8
Translation
(A) 		-1.3
Closure
(%) 		32.6
Bending Residues
( green ) 		  377 - 380
  399 - 403
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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