Proto-Oncogene Tyrosine-Protein Kinase Fes/fps

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Fes/fps
  Conformer 1
(PDB) 		3bkb (A)
  Conformer 2
(PDB) 		4e93 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 206 0.87   566 - 569   571 - 571   573 - 576   586 - 586   588 - 603   611 - 618   620 - 620   635 - 819
2 147 0.61   451 - 565   570 - 570   572 - 572   577 - 585   587 - 587   604 - 610   619 - 619   621 - 634

Sequence


           ________________________________________________________________________________________________________________560_____ 
 3bkb(A) : ***PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGE 
         :                                                                                                                          
 4e93(A) : SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ--qEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGE 
           ________________________________________________________________________________________________________________560_____ 

           ________576______585____592_______________610_____618_____________634___________________________________________________ 
 3bkb(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA 
         :                                                                                                                          
 4e93(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA 
           ________576______585____592_______________610_____618_____________634___________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3bkb(A) : ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP 
         :                                                                                                                          
 4e93(A) : ARNCLVTEKNVLKISDFGMSRE--------------vPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP 
           ________________________________________________________________________________________________________________________ 

           _________________                                                                                                        
 3bkb(A) : SFSTIYQELQSIRKRH*                                                                                                        
         :                                                                                                                          
 4e93(A) : SFSTIYQELQSIRKRHR                                                                                                        
           _________________                                                                                                        

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		8.7
Translation
(A) 		-0.3
Closure
(%) 		100.0
Bending Residues
( green ) 		  560 - 573
  576 - 577
  585 - 588
  592 - 604
  610 - 611
  618 - 621
  634 - 635
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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